InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYRIP

Summary

InnateDB Protein

IDBP-27003.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYRIP

Protein Name

myosin VIIA and Rab interacting protein

Synonyms

SLAC2-C; SLAC2C;

Species

Homo sapiens

Ensembl Protein

ENSP00000301972

InnateDB Gene

IDBG-27001 (MYRIP)

Protein Structure

UniProt Annotation

Function

Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Note=In presynaptic and postsynaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0017137	Rab GTPase binding
GO:0051018	protein kinase A binding

Biological Process

GO:0006886	intracellular protein transport
GO:0032024	positive regulation of insulin secretion

Cellular Component

GO:0000145	exocyst
GO:0001750	photoreceptor outer segment
GO:0015629	actin cytoskeleton
GO:0030133	transport vesicle
GO:0031045	dense core granule
GO:0042470	melanosome
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm