InnateDB Protein
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IDBP-270294.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mfn2
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Protein Name
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mitofusin 2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000101339
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InnateDB Gene
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IDBG-203813 (Mfn2)
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Protein Structure
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Function |
Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions. {ECO:0000269PubMed:12527753, ECO:0000269PubMed:15322553, ECO:0000269PubMed:23620051, ECO:0000269PubMed:23921556}.
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Subcellular Localization |
Mitochondrion outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalizes with BAX during apoptosis. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Expression is markedly reduced in ApoE-knockout mouse atherosclerotic arteries. {ECO:0000269PubMed:11950885, ECO:0000269PubMed:15322553}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
13
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2442230
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InterPro |
IPR001401
Dynamin, GTPase domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00350
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PRINTS |
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PIRSF |
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SMART |
SM00053
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TIGRFAMs |
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Modification |
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SwissProt |
Q80U63
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PhosphoSite |
PhosphoSite-Q80U63
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TrEMBL |
A2A7Y8
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UniProt Splice Variant |
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Entrez Gene |
170731
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UniGene |
Mm.488699
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RefSeq |
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MGI ID |
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MGI Symbol |
Mfn2
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AB048831
AF384100
AK042080
AK049583
AK052689
AK122220
AL607066
AY028170
AY123975
BC046503
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GenPept |
AAH46503
AAK27416
AAK66559
AAM88577
BAB39351
BAC33826
BAC35096
BAC65502
BAE20620
CAM23513
CAP19097
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