InnateDB Protein
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IDBP-270337.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Nmnat1
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Protein Name
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nicotinamide nucleotide adenylyltransferase 1
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Synonyms
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2610529L11Rik; 5730441G13Rik; D4Cole1e; nmnat;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000101318
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InnateDB Gene
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IDBG-205174 (Nmnat1)
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Protein Structure
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Function |
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+) (By similarity). Protects against axonal degeneration following mechanical or toxic insults. Delays axonal degeneration after axotomy. Results in a >10-fold increase in intact neurites 72 hours after injury. {ECO:0000250, ECO:0000269PubMed:15310905, ECO:0000269PubMed:16914673}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:16914673}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1913704
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InterPro |
IPR004821
Cytidyltransferase-like domain
IPR005248
Probable nicotinate-nucleotide adenylyltransferase
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PFAM |
PF01467
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9EPA7
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PhosphoSite |
PhosphoSite-Q9EPA7
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TrEMBL |
Q3V449
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UniProt Splice Variant |
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Entrez Gene |
66454
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UniGene |
Mm.76062
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RefSeq |
XP_006539168
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MGI ID |
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MGI Symbol |
Nmnat1
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OMIM |
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CCDS |
CCDS18960
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HPRD |
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IMGT |
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EMBL |
AF260924
AF260925
AF260927
AK012194
AL606973
AY679721
BC138500
BC138502
CH466594
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GenPept |
AAG17285
AAG17286
AAG38490
AAI38501
AAI38503
AAT76443
BAE43229
EDL14864
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