InnateDB Protein
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IDBP-270375.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Park7
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Protein Name
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Parkinson disease (autosomal recessive, early onset) 7
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Synonyms
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DJ-1; Dj1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000101300
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InnateDB Gene
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IDBG-205876 (Park7)
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Protein Structure
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Function |
Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone. May regulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells. {ECO:0000269PubMed:15784737, ECO:0000269PubMed:17015834, ECO:0000269PubMed:17766438, ECO:0000269PubMed:19276172, ECO:0000269PubMed:20186336, ECO:0000269PubMed:20800516, ECO:0000269PubMed:21068725, ECO:0000269PubMed:23847046}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:23847046}; Lipid-anchor {ECO:0000269PubMed:23847046}. Cytoplasm {ECO:0000250}. Membrane raft {ECO:0000269PubMed:23847046}. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage. Membrane raft localization in astrocytes and neuronal cells requires palmitoylation (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in erythroblasts and in mature red blood cells from peripheral blood (at protein level). {ECO:0000269PubMed:20800516}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.
Experimentally validated |
Total |
27
[view]
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Protein-Protein |
26
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
59 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2135637
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InterPro |
IPR002818
ThiJ/PfpI
IPR006287
DJ-1
IPR029062
Class I glutamine amidotransferase-like
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PFAM |
PF01965
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q99LX0
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PhosphoSite |
PhosphoSite-Q99LX0
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TrEMBL |
A2A817
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UniProt Splice Variant |
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Entrez Gene |
57320
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UniGene |
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RefSeq |
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MGI ID |
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MGI Symbol |
Park7
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OMIM |
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CCDS |
CCDS18975
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HPRD |
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IMGT |
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EMBL |
AB015652
AK146368
AK153948
AK168341
AL607084
BC002187
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GenPept |
AAH02187
BAA29063
BAE27118
BAE32271
BAE40278
CAM19230
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