InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Park7

Summary

InnateDB Protein

IDBP-270377.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Park7

Protein Name

Parkinson disease (autosomal recessive, early onset) 7

Synonyms

DJ-1; Dj1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101299

InnateDB Gene

IDBG-205876 (Park7)

Protein Structure

UniProt Annotation

Function

Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone. May regulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells. {ECO:0000269PubMed:15784737, ECO:0000269PubMed:17015834, ECO:0000269PubMed:17766438, ECO:0000269PubMed:19276172, ECO:0000269PubMed:20186336, ECO:0000269PubMed:20800516, ECO:0000269PubMed:21068725, ECO:0000269PubMed:23847046}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:23847046}; Lipid-anchor {ECO:0000269PubMed:23847046}. Cytoplasm {ECO:0000250}. Membrane raft {ECO:0000269PubMed:23847046}. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage. Membrane raft localization in astrocytes and neuronal cells requires palmitoylation (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in erythroblasts and in mature red blood cells from peripheral blood (at protein level). {ECO:0000269PubMed:20800516}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	59 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0004601	peroxidase activity
GO:0008233	peptidase activity
GO:0042803	protein homodimerization activity
GO:0051920	peroxiredoxin activity

Biological Process

GO:0001963	synaptic transmission, dopaminergic
GO:0006508	proteolysis
GO:0006914	autophagy
GO:0006954	inflammatory response
GO:0007005	mitochondrion organization
GO:0007338	single fertilization
GO:0008283	cell proliferation
GO:0008344	adult locomotory behavior
GO:0032091	negative regulation of protein binding
GO:0034599	cellular response to oxidative stress
GO:0034614	cellular response to reactive oxygen species
GO:0042542	response to hydrogen peroxide
GO:0042743	hydrogen peroxide metabolic process
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050727	regulation of inflammatory response
GO:0050821	protein stabilization
GO:0051583	dopamine uptake involved in synaptic transmission
GO:0051899	membrane depolarization
GO:0055114	oxidation-reduction process
GO:0060081	membrane hyperpolarization
GO:0060548	negative regulation of cell death
GO:0060765	regulation of androgen receptor signaling pathway
GO:0070301	cellular response to hydrogen peroxide
GO:2000277	positive regulation of oxidative phosphorylation uncoupler activity
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

MGI:2135637

InterPro

IPR002818 ThiJ/PfpI
IPR006287 DJ-1
IPR029062 Class I glutamine amidotransferase-like

PFAM

PF01965

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99LX0

PhosphoSite

PhosphoSite-Q99LX0

TrEMBL

A2A817

UniProt Splice Variant

Entrez Gene

57320

UniGene

RefSeq

MGI ID

MGI Symbol

Park7

OMIM

CCDS

CCDS18975

HPRD

IMGT

EMBL

AB015652 AK146368 AK153948 AK168341 AL607084 BC002187

GenPept

AAH02187 BAA29063 BAE27118 BAE32271 BAE40278 CAM19230