InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxo3

Summary

InnateDB Protein

IDBP-270751.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Foxo3

Protein Name

forkhead box O3

Synonyms

1110048B16Rik; 2010203A17Rik; C76856; Fkhr2; FKHRL1; Foxo3a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101140

InnateDB Gene

IDBG-147382 (Foxo3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	8 [view]
Protein-DNA	14 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	58 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008301	DNA binding, bending
GO:0019901	protein kinase binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001542	ovulation from ovarian follicle
GO:0001544	initiation of primordial ovarian follicle growth
GO:0001547	antral ovarian follicle growth
GO:0001556	oocyte maturation
GO:0006355	regulation of transcription, DNA-templated
GO:0007389	pattern specification process
GO:0008286	insulin receptor signaling pathway
GO:0009888	tissue development
GO:0030330	DNA damage response, signal transduction by p53 class mediator
GO:0042127	regulation of cell proliferation
GO:0042593	glucose homeostasis
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1890081

InterPro

IPR001766 Transcription factor, fork head

PFAM

PF00250

PRINTS

PR00053

PIRSF

SMART

SM00339

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

H9KUZ0

UniProt Splice Variant

Entrez Gene

56484

UniGene

Mm.466459

RefSeq

MGI ID

MGI Symbol

Foxo3

OMIM

CCDS

HPRD

IMGT

EMBL

AC116179 AC140402

GenPept