InnateDB Protein
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IDBP-270789.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Lilrb4
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Protein Name
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leukocyte immunoglobulin-like receptor, subfamily B, member 4
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Synonyms
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CD85K; gp49; Gp49b; HM18; ILT3; LIR-5;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000101122
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InnateDB Gene
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IDBG-150118 (Lilrb4)
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Protein Structure
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Function |
Receptor for class I MHC antigens. Involved in the down- regulation of the immune response and the development of tolerance. Interferes with TNFRSF5-signaling and NF-kappa-B up- regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
2
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:102701
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InterPro |
IPR007110
Immunoglobulin-like domain
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q64281
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PhosphoSite |
PhosphoSite-Q64281
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
14728
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UniGene |
Mm.415422
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RefSeq |
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MGI ID |
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MGI Symbol |
Lilrb4
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC006591
U05264
U05265
U05266
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GenPept |
AAA17796
AAA17797
AAA17798
AAA17799
AAH06591
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