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InnateDB Protein
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IDBP-270791.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Lilrb4
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Protein Name
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leukocyte immunoglobulin-like receptor, subfamily B, member 4
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Synonyms
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CD85K; gp49; Gp49b; HM18; ILT3; LIR-5;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000101121
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InnateDB Gene
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IDBG-150118 (Lilrb4)
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Protein Structure
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| Function |
Receptor for class I MHC antigens. Involved in the down- regulation of the immune response and the development of tolerance. Interferes with TNFRSF5-signaling and NF-kappa-B up- regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment. {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
3
[view]
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| Protein-Protein |
2
[view]
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| Protein-DNA |
1
[view]
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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Molecular Function |
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| Biological Process |
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| Cellular Component |
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| PDB ID |
MGI:102701
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| InterPro |
IPR007110
Immunoglobulin-like domain
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q64281
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| PhosphoSite |
PhosphoSite-Q64281
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
14728
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| UniGene |
Mm.415422
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| RefSeq |
NP_001278823
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| MGI ID |
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| MGI Symbol |
Lilrb4
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
BC006591
U05264
U05265
U05266
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| GenPept |
AAA17796
AAA17797
AAA17798
AAA17799
AAH06591
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Version 5.4