InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Man1a

Summary

InnateDB Protein

IDBP-270815.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Man1a

Protein Name

mannosidase 1, alpha

Synonyms

Man1a1; PCR1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101110

InnateDB Gene

IDBG-151744 (Man1a)

Protein Structure

UniProt Annotation

Function

Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).

Subcellular Localization

Golgi apparatus membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509	calcium ion binding

Biological Process

GO:0006486

protein glycosylation

Cellular Component

GO:0000139	Golgi membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:104677

InterPro

IPR001382 Glycoside hydrolase, family 47

PFAM

PF01532

PRINTS

PR00747

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P45700

PhosphoSite

PhosphoSite-P45700

TrEMBL

Q544T7

UniProt Splice Variant

Entrez Gene

17155

UniGene

Mm.408047

RefSeq

MGI ID

1NXC

MGI Symbol

Man1a

OMIM

CCDS

CCDS23848

HPRD

IMGT

EMBL

AK031038 AK154820 BC015265 CH466540 U04299

GenPept

AAA17747 AAH15265 BAC27225 BAE32852 EDL05098 EDL05100