InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adora2a

Summary

InnateDB Protein

IDBP-270916.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adora2a

Protein Name

adenosine A2a receptor

Synonyms

A2AAR; A2aR; AA2AR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101060

InnateDB Gene

IDBG-162633 (Adora2a)

Protein Structure

UniProt Annotation

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001609	G-protein coupled adenosine receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0031802	type 5 metabotropic glutamate receptor binding
GO:0042802	identical protein binding
GO:0046982	protein heterodimerization activity
GO:0051393	alpha-actinin binding

Biological Process

GO:0001963	synaptic transmission, dopaminergic
GO:0001973	adenosine receptor signaling pathway
GO:0001975	response to amphetamine
GO:0006355	regulation of transcription, DNA-templated
GO:0006469	negative regulation of protein kinase activity
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007271	synaptic transmission, cholinergic
GO:0007626	locomotory behavior
GO:0008285	negative regulation of cell proliferation
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0014049	positive regulation of glutamate secretion
GO:0014057	positive regulation of acetylcholine secretion
GO:0014061	regulation of norepinephrine secretion
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031000	response to caffeine
GO:0032230	positive regulation of synaptic transmission, GABAergic
GO:0035249	synaptic transmission, glutamatergic
GO:0035810	positive regulation of urine volume
GO:0035815	positive regulation of renal sodium excretion
GO:0040013	negative regulation of locomotion
GO:0042311	vasodilation
GO:0042493	response to drug
GO:0042755	eating behavior
GO:0043116	negative regulation of vascular permeability
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043279	response to alkaloid
GO:0043524	negative regulation of neuron apoptotic process
GO:0045938	positive regulation of circadian sleep/wake cycle, sleep
GO:0046636	negative regulation of alpha-beta T cell activation
GO:0048143	astrocyte activation
GO:0048167	regulation of synaptic plasticity
GO:0048812	neuron projection morphogenesis
GO:0050714	positive regulation of protein secretion
GO:0050728	negative regulation of inflammatory response
GO:0051881	regulation of mitochondrial membrane potential
GO:0051899	membrane depolarization
GO:0051924	regulation of calcium ion transport
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060080	regulation of inhibitory postsynaptic membrane potential
GO:0060134	prepulse inhibition
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005882	intermediate filament
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0012505	endomembrane system
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0030673	axolemma
GO:0032279	asymmetric synapse
GO:0042734	presynaptic membrane
GO:0043025	neuronal cell body
GO:0045211	postsynaptic membrane
GO:0048786	presynaptic active zone

Protein Structure and Domains

PDB ID

MGI:99402

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001513 Adenosine A2A receptor
IPR001634 Adenosine receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00553
PR00424

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q60613