InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trpm2

Summary

InnateDB Protein

IDBP-270958.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trpm2

Protein Name

transient receptor potential cation channel, subfamily M, member 2

Synonyms

9830168K16Rik; C79133; LTRPC2; Trp7; TRPC7; Trrp7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101040

InnateDB Gene

IDBG-167747 (Trpm2)

Protein Structure

UniProt Annotation

Function

Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Has ADP-ribose pyrophosphatase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000269PubMed:11804595}; Multi-pass membrane protein {ECO:0000269PubMed:11804595}.

Disease Associations

Tissue Specificity

Widely expressed, with highest levels in lung, spleen, eye and brain. {ECO:0000269PubMed:11804595}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005262	calcium channel activity
GO:0005272	sodium channel activity
GO:0005384	manganese ion transmembrane transporter activity
GO:0016787	hydrolase activity
GO:0047631	ADP-ribose diphosphatase activity

Biological Process

GO:0006811	ion transport
GO:0006828	manganese ion transport
GO:0008152	metabolic process
GO:0033194	response to hydroperoxide
GO:0035725	sodium ion transmembrane transport
GO:0045087	innate immune response (InnateDB)
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0071421	manganese ion transmembrane transport