InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arid3a

Summary

InnateDB Protein

IDBP-271007.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arid3a

Protein Name

AT rich interactive domain 3A (BRIGHT-like)

Synonyms

Bright; Dri1; Dril1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101016

InnateDB Gene

IDBG-171662 (Arid3a)

Protein Structure

UniProt Annotation

Function

Transcription factor involved in B-cell differentiation. Binds a VH promoter proximal site necessary for induced mu-heavy- chain transcription. Binds the minor groove of a restricted ATC sequence that is sufficient for nuclear matrix association. This sequence motif is present in matrix-associating regions (MARS) proximal to the promoter and flanking E mu. Activates E mu-driven transcription by binding these sites. May be involved in the control of cell cycle progression by the RB1/E2F1 pathway. {ECO:0000269PubMed:11294836, ECO:0000269PubMed:17312145, ECO:0000269PubMed:8543152}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm.

Disease Associations

Tissue Specificity

B-cell specific in the adult. Expressed in B- cell progenitors, down-regulated in the immature B-cell stage, and is up-regulated again at later stages of B-lymphocyte differentiation. {ECO:0000269PubMed:9590220}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	3 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

MGI:1328360

InterPro

IPR001606 ARID/BRIGHT DNA-binding domain

PFAM

PF01388

PRINTS

PIRSF

SMART

SM00501

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q62431

PhosphoSite

PhosphoSite-Q62431

TrEMBL

D3YVQ2

UniProt Splice Variant

Entrez Gene

13496

UniGene

Mm.471456

RefSeq

MGI ID

MGI Symbol

Arid3a

OMIM

CCDS

HPRD

IMGT

EMBL

AC151846 AK141283 AK154956 BC050925 U60335

GenPept

AAB03416 AAH50925 BAE24635 BAE32951