Version 5.4
Mus musculus Protein: Gamt
Summary
InnateDB Protein IDBP-271035.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gamt
Protein Name guanidinoacetate methyltransferase
Synonyms AA571402; Spintz1;
Species Mus musculus
Ensembl Protein ENSMUSP00000101002
InnateDB Gene IDBG-173403 (Gamt)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cell projection, microvillus {ECO:0000269PubMed:8312439}. Note=Detected in microvilli of the epithelial cells lining the caput epididymis.
Disease Associations
Tissue Specificity Highly expressed in testis, caput epididymis, ovary, and liver. In the testis, localized primarily in Sertoli cells. Expressed in brain with high levels in oligodendrocytes and olfactory ensheathing glia. Moderate levels of expression in astrocytes. {ECO:0000269PubMed:15245487, ECO:0000269PubMed:8312439}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0030731 guanidinoacetate N-methyltransferase activity
Biological Process
GO:0006601 creatine biosynthetic process
GO:0007283 spermatogenesis
GO:0009887 organ morphogenesis
GO:0032259 methylation
GO:0040014 regulation of multicellular organism growth
Cellular Component
GO:0005902 microvillus
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1098221
InterPro IPR016550 Guanidinoacetate N-methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM
PRINTS
PIRSF PIRSF009285
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35969
PhosphoSite PhosphoSite-O35969
TrEMBL
UniProt Splice Variant
Entrez Gene 14431
UniGene
RefSeq NP_034385
MGI ID
MGI Symbol Gamt
OMIM
CCDS CCDS35976
HPRD
IMGT
EMBL AF010498 AF010499 AF015887 AK140688 AK158087 BC049233
GenPept AAB81495 AAB81498 AAH49233 BAE24443 BAE34352

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca