Version 5.4
Mus musculus Protein: Reep6
Summary
InnateDB Protein IDBP-271053.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Reep6
Protein Name receptor accessory protein 6
Synonyms 0610011M24Rik; Dp1l1;
Species Mus musculus
Ensembl Protein ENSMUSP00000100992
InnateDB Gene IDBG-173745 (Reep6)
Protein Structure
UniProt Annotation
Function May play a role in intracellular protein transport from the endoplasmic reticulum to the cell surface (PubMed:24098485). May play a role in retinal development (PubMed:24691551). {ECO:0000269PubMed:24098485, ECO:0000269PubMed:24691551}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:24098485}; Multi-pass membrane protein {ECO:0000269PubMed:24098485}.
Disease Associations
Tissue Specificity Expressed in retinal rod photoreceptors and in liver, but not detected in brain, muscle, kidney, retinal cone photoreceptors or retinal ganglion cells (at protein level) (PubMed:24691551). Highly expressed in the ganglion cell layer of the retina and in liver, and also detected at low levels in kidney and testis (PubMed:15728532). Isoform 1 is expressed in the retina. Isoform 2 is expressed in liver. {ECO:0000269PubMed:15728532, ECO:0000269PubMed:24691551}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
GO:0032386 regulation of intracellular transport
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0045177 apical part of cell
Protein Structure and Domains
PDB ID MGI:1917585
InterPro IPR004345 TB2/DP1/HVA22-related protein
PFAM PF03134
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JM62
PhosphoSite PhosphoSite-Q9JM62
TrEMBL
UniProt Splice Variant
Entrez Gene 70335
UniGene Mm.28147
RefSeq NP_001191860
MGI ID
MGI Symbol Reep6
OMIM
CCDS CCDS56735
HPRD
IMGT
EMBL AB039933 AY562234 BC029741
GenPept AAH29741 AAT70679 BAA94544

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca