InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GTF2H2

Summary

InnateDB Protein

IDBP-27107.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GTF2H2

Protein Name

general transcription factor IIH, polypeptide 2, 44kDa

Synonyms

BTF2; BTF2P44; p44; T-BTF2P44; TFIIH;

Species

Homo sapiens

Ensembl Protein

ENSP00000274400

InnateDB Gene

IDBG-27105 (GTF2H2)

Protein Structure

UniProt Annotation

Function

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C- terminus is required for a successful escape of RNAP II form the promoter.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Widely expressed, with higher expression in skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004672	protein kinase activity
GO:0005515	protein binding
GO:0008094	DNA-dependent ATPase activity
GO:0008135	translation factor activity, nucleic acid binding
GO:0008270	zinc ion binding
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0000718	nucleotide-excision repair, DNA damage removal
GO:0002031	G-protein coupled receptor internalization
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006360	transcription from RNA polymerase I promoter
GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006362	transcription elongation from RNA polymerase I promoter
GO:0006363	termination of RNA polymerase I transcription
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006370	7-methylguanosine mRNA capping
GO:0006412	translation
GO:0006468	protein phosphorylation
GO:0009411	response to UV
GO:0010467	gene expression
GO:0016032	viral process
GO:0050434	positive regulation of viral transcription