InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Map2k2

Summary

InnateDB Protein

IDBP-271102.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Map2k2

Protein Name

mitogen-activated protein kinase kinase 2

Synonyms

AA589381; MEK2; MK2; Prkmk2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000100968

InnateDB Gene

IDBG-176971 (Map2k2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004708	MAP kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030165	PDZ domain binding
GO:0043539	protein serine/threonine kinase activator activity
GO:0097110	scaffold protein binding

Biological Process

GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0006468	protein phosphorylation
GO:0036289	peptidyl-serine autophosphorylation

Cellular Component

GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005911	cell-cell junction
GO:0005938	cell cortex
GO:0009898	cytoplasmic side of plasma membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1346867

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt