Mus musculus Protein: Kera
Summary
InnateDB Protein IDBP-271202.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kera
Protein Name keratocan
Synonyms CNA2; SLRR2B;
Species Mus musculus
Ensembl Protein ENSMUSP00000100923
InnateDB Gene IDBG-187555 (Kera)
Protein Structure
UniProt Annotation
Function May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.
Subcellular Localization Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Disease Associations
Tissue Specificity Selectively expressed in cornea of adult where it is detected in keratocytes but not in scleral cells. In embryo, first detected in periocular mesenchymal cells migrating toward developing cornea on E13.5; expression gradually restricted to corneal stromal cells on E14.5 to E18.5. Detected in scleral cells of E15.5 but not in E18.5 embryos.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0061303 cornea development in camera-type eye
Cellular Component
GO:0005578 proteinaceous extracellular matrix
Protein Structure and Domains
PDB ID MGI:1202398
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
PFAM PF01462
PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART SM00013
SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35367
PhosphoSite PhosphoSite-O35367
TrEMBL A4FUJ3
UniProt Splice Variant
Entrez Gene 16545
UniGene Mm.6228
RefSeq NP_032464
MGI ID
MGI Symbol Kera
OMIM
CCDS CCDS36044
HPRD
IMGT
EMBL AF022256 AF057301 BC114980 CH466539
GenPept AAC15505 AAC61257 AAI14981 EDL21632