Version 5.4
Mus musculus Protein: Slc16a7
Summary
InnateDB Protein IDBP-271263.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc16a7
Protein Name solute carrier family 16 (monocarboxylic acid transporters), member 7
Synonyms 4921534N07Rik; Mct2;
Species Mus musculus
Ensembl Protein ENSMUSP00000100892
InnateDB Gene IDBG-193628 (Slc16a7)
Protein Structure
UniProt Annotation
Function Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter. {ECO:0000269PubMed:21792931}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in testis and in spermatozoa (at protein level). {ECO:0000269PubMed:21792931}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015129 lactate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015355 secondary active monocarboxylate transmembrane transporter activity
GO:0050833 pyruvate transmembrane transporter activity
Biological Process
GO:0015711 organic anion transport
GO:0035873 lactate transmembrane transport
GO:0055085 transmembrane transport
GO:1901475 pyruvate transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1330284
InterPro IPR004743 Monocarboxylate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain
PFAM PF07690
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O70451
PhosphoSite PhosphoSite-O70451
TrEMBL Q149G3
UniProt Splice Variant
Entrez Gene 20503
UniGene Mm.394644
RefSeq XP_006513469
MGI ID
MGI Symbol Slc16a7
OMIM
CCDS CCDS24218
HPRD
IMGT
EMBL AF058054 AK076612 BC117804 BC126960 CH466578
GenPept AAC13719 AAI17805 AAI26961 BAC36415 EDL24444 EDL24445

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca