Version 5.4
Mus musculus Protein: Ctdsp2
Summary
InnateDB Protein IDBP-271266.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ctdsp2
Protein Name CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
Synonyms AI586070; D10Ertd73e; OS-4; OS4; SCP2;
Species Mus musculus
Ensembl Protein ENSMUSP00000100891
InnateDB Gene IDBG-271264 (Ctdsp2)
Protein Structure
UniProt Annotation
Function Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Expression is restricted to non-neuronal tissues. {ECO:0000269PubMed:15681389}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008420 CTD phosphatase activity
GO:0016791 phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0006470 protein dephosphorylation
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1098748
InterPro IPR004274 NLI interacting factor
IPR011948 Dullard phosphatase domain, eukaryotic
IPR023214 HAD-like domain
PFAM PF03031
PF00702
PF08282
PF13419
PRINTS
PIRSF
SMART SM00577
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BX07
PhosphoSite PhosphoSite-
TrEMBL Q8R3B3
UniProt Splice Variant
Entrez Gene 52468
UniGene Mm.29490
RefSeq NP_001106941
MGI ID
MGI Symbol Ctdsp2
OMIM
CCDS CCDS48711
HPRD
IMGT
EMBL AC134329 AK049271 BC025650 BC085142 BC089307
GenPept AAH25650 AAH85142 AAH89307 BAC33649

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca