InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sarnp

Summary

InnateDB Protein

IDBP-271322.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sarnp

Protein Name

SAP domain containing ribonucleoprotein

Synonyms

1110005A23Rik; Cip29;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000100863

InnateDB Gene

IDBG-271320 (Sarnp)

Protein Structure

UniProt Annotation

Function

Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single- stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006406	mRNA export from nucleus
GO:0006417	regulation of translation