InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: H2afb1

Summary

InnateDB Protein

IDBP-272019.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H2afb1

Protein Name

H2A histone family, member B1

Synonyms

1700113O17Rik; H2A.Bbd; H2al2; TSEG-1; Tseg1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000100618

InnateDB Gene

IDBG-139252 (H2afb1)

Protein Structure

UniProt Annotation

Function

Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing (By similarity). May participate in spermatogenesis. {ECO:0000250}.

Subcellular Localization

Nucleus. Chromosome. Note=Associated with the active X chromosome and with autosomes, while it is absent from the inactive X chromosome and excluded from Barr bodies. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in adult testis, mainly in spermatocytes. {ECO:0000269PubMed:20008104, ECO:0000269PubMed:20188161}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006334	nucleosome assembly
GO:0006397	mRNA processing

Cellular Component

GO:0000786	nucleosome
GO:0000788	nuclear nucleosome
GO:0005622	intracellular
GO:0005634	nucleus
GO:0035327	transcriptionally active chromatin

Protein Structure and Domains

PDB ID

MGI:1915481

InterPro

IPR002119 Histone H2A
IPR003958 Transcription factor CBF/NF-Y/archaeal histone
IPR007125 Histone core
IPR009072 Histone-fold

PFAM

PF00808
PF00125

PRINTS

PR00620

PIRSF

SMART

SM00414

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CQ70

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

68231

UniGene

RefSeq

NP_080903

MGI ID

MGI Symbol

H2afb1

OMIM

CCDS

CCDS38050

HPRD

IMGT

EMBL

AK006586 AK015538 AK018839 AK018922 AK018951 AK018962 AK160415 AL928589 BC061062 CH466542 EU079024

GenPept

AAH61062 ABU52995 BAB24661 BAB29887 BAB31458 BAB31484 BAB31492 BAB31496 BAE35779 CAM21795 EDL08091