Version 5.4
Mus musculus Protein: Hist2h2aa1
Summary
InnateDB Protein IDBP-272122.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hist2h2aa1
Protein Name histone cluster 2, H2aa1
Synonyms AI448581; H2a-614; H2a-615; Hist2;
Species Mus musculus
Ensembl Protein ENSMUSP00000100581
InnateDB Gene IDBG-215926 (Hist2h2aa1)
Protein Structure
UniProt Annotation
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization Nucleus. Chromosome.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
GO:0008150 biological_process
Cellular Component
GO:0000786 nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:96097
InterPro IPR002119 Histone H2A
IPR003958 Transcription factor CBF/NF-Y/archaeal histone
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00808
PF00125
PRINTS PR00620
PIRSF
SMART SM00414
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6GSS7
PhosphoSite PhosphoSite-Q6GSS7
TrEMBL F8WIX8
UniProt Splice Variant
Entrez Gene 667728
UniGene
RefSeq NP_835584
MGI ID
MGI Symbol Hist2h2aa1
OMIM
CCDS CCDS57241
HPRD
IMGT
EMBL AC160122 AK002725 AK006728 AY158924 AY158925 AY158953 BC010564 BC062255 BC089519 BC147778 BC147781 CH466620 U62674 X16148
GenPept AAB04770 AAH10564 AAH62255 AAH89519 AAI47779 AAI47782 AAO06234 AAO06235 AAO06263 BAB22310 BAB24717 CAA34273 EDL38878

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca