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InnateDB Protein
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IDBP-272198.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Capns2
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Protein Name
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calpain, small subunit 2
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Synonyms
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2310005G05Rik; 30K-2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000100553
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InnateDB Gene
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IDBG-272196 (Capns2)
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Protein Structure
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| Function |
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocates to the plasma membrane upon calcium binding. {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
1 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0004198
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calcium-dependent cysteine-type endopeptidase activity
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GO:0005509
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calcium ion binding
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| Biological Process |
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| Cellular Component |
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| PDB ID |
MGI:1916793
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| InterPro |
IPR002048
EF-hand domain
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| PFAM |
PF00036
PF13202
PF13405
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| PRINTS |
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| PIRSF |
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| SMART |
SM00054
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q9D7J7
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| PhosphoSite |
PhosphoSite-Q9D7J7
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
69543
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| UniGene |
Mm.440514
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| RefSeq |
NP_081388
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| MGI ID |
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| MGI Symbol |
Capns2
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| OMIM |
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| CCDS |
CCDS52634
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| HPRD |
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| IMGT |
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| EMBL |
AK009171
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| GenPept |
BAB26120
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Version 5.4