InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTF1

Summary

InnateDB Protein

IDBP-27221.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTF1

Protein Name

cardiotrophin 1

Synonyms

CT-1; CT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000279804

InnateDB Gene

IDBG-27219 (CTF1)

Protein Structure

UniProt Annotation

Function

Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005146	leukemia inhibitory factor receptor binding

Biological Process

GO:0007267	cell-cell signaling
GO:0007399	nervous system development
GO:0007517	muscle organ development
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0048666	neuron development
GO:0048861	leukemia inhibitory factor signaling pathway