InnateDB Protein
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IDBP-27277.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MBOAT2
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Protein Name
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membrane bound O-acyltransferase domain containing 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000302177
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InnateDB Gene
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IDBG-27273 (MBOAT2)
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Protein Structure
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Function |
Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3- phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2- diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269PubMed:18772128}.
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Subcellular Localization |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in neutrophils. {ECO:0000269PubMed:18772128}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0003841
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1-acylglycerol-3-phosphate O-acyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004299
Membrane bound O-acyl transferase, MBOAT
IPR016196
Major facilitator superfamily domain, general substrate transporter
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PFAM |
PF03062
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6ZWT7
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PhosphoSite |
PhosphoSite-Q6ZWT7
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TrEMBL |
B0AZU0
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UniProt Splice Variant |
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Entrez Gene |
129642
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UniGene |
Hs.712689
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RefSeq |
NP_620154
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HUGO |
HGNC:25193
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OMIM |
611949
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CCDS |
CCDS1660
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HPRD |
11410
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IMGT |
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EMBL |
AB305044
AC012495
AC112723
AK027321
AK074779
AK315881
BC016005
BC146871
BC157827
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GenPept |
AAH16005
AAI46872
AAI57828
BAC11204
BAC85105
BAF93900
BAF98772
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