InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BET1

Summary

InnateDB Protein

IDBP-27282.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BET1

Protein Name

blocked early in transport 1 homolog (S. cerevisiae)

Synonyms

HBET1;

Species

Homo sapiens

Ensembl Protein

ENSP00000222547

InnateDB Gene

IDBG-27278 (BET1)

Protein Structure

UniProt Annotation

Function

Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	8 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019905	syntaxin binding

Biological Process

GO:0006888	ER to Golgi vesicle-mediated transport
GO:0015031	protein transport
GO:0048280	vesicle fusion with Golgi apparatus

Cellular Component

GO:0000139	Golgi membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005801	cis-Golgi network
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031985	Golgi cisterna