InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADAMTSL3

Summary

InnateDB Protein

IDBP-27285.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAMTSL3

Protein Name

ADAMTS-like 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000286744

InnateDB Gene

IDBG-27283 (ADAMTSL3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:14667842}.

Disease Associations

Tissue Specificity

Expressed in epithelial cells of the colon, fallopian tube, skin, breast, prostate, epididymis, liver, pancreatic islets and bile ducts, as well as by vascular endothelial cells, smooth muscle cells, fibroblasts, cortical and ganglionic neurons and cardiac myocytes. Also expressed by malignant epithelial cells in colon cancer, as well as breast, prostate, renal and skin tumors. Expression is significantly reduced in colon cancer compared to normal colon. {ECO:0000269PubMed:14667842, ECO:0000269PubMed:17597111}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005578

proteinaceous extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000884 Thrombospondin, type 1 repeat
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR010909 PLAC
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
IPR013273 Peptidase M12B, ADAM-TS

PFAM

PF00090
PF08686
PF07679
PF00047

PRINTS

PR01857

PIRSF

SMART

SM00209
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt