Version 5.4
Homo sapiens Protein: ORAI3
Summary
InnateDB Protein IDBP-27346.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ORAI3
Protein Name ORAI calcium release-activated calcium modulator 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000322249
InnateDB Gene IDBG-27344 (ORAI3)
Protein Structure
UniProt Annotation
Function Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002115 store-operated calcium entry
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR012446 Calcium release-activated calcium channel protein
PFAM PF07856
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BRQ5
PhosphoSite PhosphoSite-Q9BRQ5
TrEMBL A0A024QZA7
UniProt Splice Variant
Entrez Gene 93129
UniGene Hs.741899
RefSeq NP_689501
HUGO HGNC:28185
OMIM 610930
CCDS CCDS10697
HPRD 14431
IMGT
EMBL BC006126 BC015555 BC022786 CH471192
GenPept AAH06126 AAH15555 AAH22786 EAW52185 EAW52186

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca