Version 5.4
Mus musculus Protein: Wash
Summary
InnateDB Protein IDBP-273831.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wash
Protein Name open reading frame 19
Synonyms 1110049F14Rik; ORF19; Wash1;
Species Mus musculus
Ensembl Protein ENSMUSP00000112255
InnateDB Gene IDBG-195355 (Wash)
Protein Structure
UniProt Annotation
Function Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000269PubMed:19922875}.
Subcellular Localization Early endosome membrane {ECO:0000269PubMed:19922875}. Recycling endosome membrane {ECO:0000269PubMed:19922875}. Note=Localization to the endodome membrane is mediated via its interaction with FAM21.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:19922875}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0043014 alpha-tubulin binding
Biological Process
GO:0016197 endosomal transport
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0042147 retrograde transport, endosome to Golgi
Cellular Component
GO:0005769 early endosome
GO:0031901 early endosome membrane
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0071203 WASH complex
Protein Structure and Domains
PDB ID MGI:1916017
InterPro IPR003124 WH2 domain
IPR021854 WASH1, WAHD domain
PFAM PF02205
PF11945
PRINTS
PIRSF
SMART SM00246
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VDD8
PhosphoSite PhosphoSite-Q8VDD8
TrEMBL
UniProt Splice Variant
Entrez Gene 68767
UniGene Mm.296545
RefSeq NP_001032846
MGI ID
MGI Symbol Wash
OMIM
CCDS CCDS28944
HPRD
IMGT
EMBL AJ304796 AK033616 AK149967 AK154400 AK159820 AK171737 AK172673 BC025839
GenPept AAH25839 BAC28393 BAE29201 BAE32561 BAE35400 BAE42641 BAE43124 CAC83096

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca