InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trmt112

Summary

InnateDB Protein

IDBP-273841.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trmt112

Protein Name

tRNA methyltransferase 11-2 homolog (S. cerevisiae)

Synonyms

0610038D11Rik; Trm112p;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112250

InnateDB Gene

IDBG-137039 (Trmt112)

Protein Structure

UniProt Annotation

Function

Participates both in methylation of protein and tRNA species. The heterodimer with HEMK2/N6AMT1 catalyzes N5- methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008276	protein methyltransferase activity

Biological Process

GO:0006479	protein methylation
GO:0018364	peptidyl-glutamine methylation

Cellular Component

GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1914924

InterPro

IPR005651 Uncharacterised protein family UPF0434/Trm112

PFAM

PF03966

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9DCG9

PhosphoSite

PhosphoSite-Q9DCG9

TrEMBL

UniProt Splice Variant

Entrez Gene

67674

UniGene

Mm.371597

RefSeq

NP_001159842

MGI ID

MGI Symbol

Trmt112

OMIM

CCDS

CCDS29508

HPRD

IMGT

EMBL

AK002791 AK003292 BC016191

GenPept

AAH16191 BAB22361 BAB22695