InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trappc2

Summary

InnateDB Protein

IDBP-273984.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trappc2

Protein Name

trafficking protein particle complex 2

Synonyms

1110066L09Rik; 1810064C02Rik; AW496358; MIP-2A; Sedl; TRS20;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112195

InnateDB Gene

IDBG-256512 (Trappc2)

Protein Structure

UniProt Annotation

Function

Prevents ENO1-mediated transcriptional repression and antagonizes ENO1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus {ECO:0000269PubMed:19650763}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000269PubMed:19650763}. Endoplasmic reticulum {ECO:0000269PubMed:19650763}. Note=Localized in perinuclear granular structures.

Disease Associations

Tissue Specificity

Expressed in chondrocytes at various stages of differentiation, including proliferating, prehypertrophic and hypertrophic chondrocytes in the distal femoral joint. {ECO:0000269PubMed:19650763}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006810	transport
GO:0006888	ER to Golgi vesicle-mediated transport

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005801	cis-Golgi network
GO:0048471	perinuclear region of cytoplasm