InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Klkb1

Summary

InnateDB Protein

IDBP-274040.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klkb1

Protein Name

kallikrein B, plasma 1

Synonyms

APS; Kal-3; Kal3; Klk3; PSA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112174

InnateDB Gene

IDBG-152284 (Klkb1)

Protein Structure

UniProt Annotation

Function

The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0006508	proteolysis
GO:0006954	inflammatory response
GO:0007596	blood coagulation
GO:0031639	plasminogen activation
GO:0042730	fibrinolysis
GO:0051919	positive regulation of fibrinolysis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

MGI:102849

InterPro

IPR000177 Apple domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR003014 PAN-1 domain
IPR003609 Apple-like
IPR009003 Trypsin-like cysteine/serine peptidase domain

PFAM

PF00089
PF00024

PRINTS

PR00005
PR00722

PIRSF

SMART

SM00223
SM00020
SM00473

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt