InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mphosph8

Summary

InnateDB Protein

IDBP-274053.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mphosph8

Protein Name

M-phase phosphoprotein 8

Synonyms

1500035L22Rik; 4930548G07Rik; AU040635;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112170

InnateDB Gene

IDBG-258449 (Mphosph8)

Protein Structure

UniProt Annotation

Function

Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Detected on heterochromatin. Detected on nucleosomes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0035064	methylated histone binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0044030	regulation of DNA methylation
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0000788	nuclear nucleosome
GO:0005634	nucleus
GO:0005720	nuclear heterochromatin
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1922589

InterPro

IPR000953 Chromo domain/shadow
IPR002110 Ankyrin repeat
IPR016197 Chromo domain-like
IPR020683 Ankyrin repeat-containing domain
IPR023780 Chromo domain

PFAM

PF00023
PF13606
PF11929
PF12796
PF00385

PRINTS

PR01415

PIRSF

SMART

SM00298
SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt