InnateDB Protein
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IDBP-274289.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mprip
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Protein Name
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myosin phosphatase Rho interacting protein
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Synonyms
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9530046C02; AA536749; AI647711; C76423; mKIAA0864; p116Rip; Rhoip3; RIP3;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000112072
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InnateDB Gene
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IDBG-179147 (Mprip)
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Protein Structure
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Function |
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F- actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000269PubMed:12732640, ECO:0000269PubMed:15469989}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000269PubMed:12732640}. Note=Colocalizes with F-actin.
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Disease Associations |
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Tissue Specificity |
Expressed in Kidney, Brain, Heart and Lung. {ECO:0000269PubMed:9199174}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
23 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1349438
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InterPro |
IPR001849
Pleckstrin homology domain
IPR009078
Ferritin-like superfamily
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PFAM |
PF00169
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PRINTS |
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PIRSF |
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SMART |
SM00233
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TIGRFAMs |
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Modification |
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SwissProt |
P97434
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PhosphoSite |
PhosphoSite-P97434
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
26936
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UniGene |
Mm.327678
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RefSeq |
NP_036157
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MGI ID |
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MGI Symbol |
Mprip
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OMIM |
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CCDS |
CCDS24775
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HPRD |
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IMGT |
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EMBL |
AK154807
AK155630
AK158296
AK162530
AK170849
AK171089
AL596204
BC049803
BC063067
U73200
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GenPept |
AAB18198
AAH49803
AAH63067
BAE32843
BAE33355
BAE34450
BAE36957
BAE42072
BAE42242
CAI24300
CAI24303
CAI24304
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