InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Xylt2

Summary

InnateDB Protein

IDBP-274338.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Xylt2

Protein Name

xylosyltransferase II

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112052

InnateDB Gene

IDBG-209185 (Xylt2)

Protein Structure

UniProt Annotation

Function

Probably catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0008375	acetylglucosaminyltransferase activity
GO:0030158	protein xylosyltransferase activity

Biological Process

GO:0006024	glycosaminoglycan biosynthetic process
GO:0007165	signal transduction
GO:0015012	heparan sulfate proteoglycan biosynthetic process
GO:0030166	proteoglycan biosynthetic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0030210	heparin biosynthetic process