InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DAD1

Summary

InnateDB Protein

IDBP-2749.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAD1

Protein Name

defender against cell death 1

Synonyms

OST2;

Species

Homo sapiens

Ensembl Protein

ENSP00000250498

InnateDB Gene

IDBG-2747 (DAD1)

Protein Structure

UniProt Annotation

Function

Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Loss of the DAD1 protein triggers apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004576	oligosaccharyl transferase activity
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity

Biological Process

GO:0001824	blastocyst development
GO:0006486	protein glycosylation
GO:0006915	apoptotic process
GO:0007584	response to nutrient
GO:0018279	protein N-linked glycosylation via asparagine
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0008250	oligosaccharyltransferase complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome