InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Esrp2

Summary

InnateDB Protein

IDBP-275435.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Esrp2

Protein Name

epithelial splicing regulatory protein 2

Synonyms

9530027K23Rik; Rbm35b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111639

InnateDB Gene

IDBG-394189 (Esrp2)

Protein Structure

UniProt Annotation

Function

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Epithelial cell-specific. {ECO:0000269PubMed:14681479}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0004969	histamine receptor activity
GO:0044822	poly(A) RNA binding