Version 5.4
Homo sapiens Protein: ZNF366
Summary
InnateDB Protein IDBP-27732.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZNF366
Protein Name zinc finger protein 366
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000313158
InnateDB Gene IDBG-27728 (ZNF366)
Protein Structure
UniProt Annotation
Function Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases. {ECO:0000269PubMed:17085477}.
Subcellular Localization Nucleus {ECO:0000269PubMed:17085477}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0030331 estrogen receptor binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0043627 response to estrogen
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N895
PhosphoSite PhosphoSite-Q8N895
TrEMBL F8W732
UniProt Splice Variant
Entrez Gene 167465
UniGene
RefSeq NP_689838
HUGO HGNC:18316
OMIM 610159
CCDS CCDS4015
HPRD 18329
IMGT
EMBL AC008457 AC093278 AK097115 BC121053 BK000210 BX647592 CH471084
GenPept AAI21054 BAC04954 CAI46096 DAA00066 EAW95707

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca