InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MMP16

Summary

InnateDB Protein

IDBP-27858.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP16

Protein Name

matrix metallopeptidase 16 (membrane-inserted)

Synonyms

C8orf57; MMP-X2; MT-MMP2; MT-MMP3; MT3-MMP;

Species

Homo sapiens

Ensembl Protein

ENSP00000286614

InnateDB Gene

IDBG-27856 (MMP16)

Protein Structure

UniProt Annotation

Function

Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. {ECO:0000269PubMed:11278606}.

Subcellular Localization

Isoform Long: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}. Note=Localized at the cell surface of melanoma cells.Isoform Short: Secreted, extracellular space, extracellular matrix. Cell surface. Note=Localized at the cell surface of melanoma cells.

Disease Associations

Tissue Specificity

Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0008047	enzyme activator activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0001503	ossification
GO:0001958	endochondral ossification
GO:0006508	proteolysis
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0035988	chondrocyte proliferation
GO:0043085	positive regulation of catalytic activity
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0060348	bone development
GO:0097094	craniofacial suture morphogenesis

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000585 Hemopexin-like domain
IPR001818 Peptidase M10, metallopeptidase
IPR002477 Peptidoglycan binding-like
IPR006026 Peptidase, metallopeptidase
IPR016293 Peptidase M10A, stromelysin-type
IPR018487 Hemopexin-like repeats
IPR021190 Peptidase M10A
IPR021805 Peptidase M10A, matrix metallopeptidase, C-terminal

PFAM

PF00413
PF01471
PF00045
PF11857

PRINTS

PR00138

PIRSF

PIRSF001191

SMART

SM00235
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References