InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRSS8

Summary

InnateDB Protein

IDBP-27863.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRSS8

Protein Name

protease, serine, 8

Synonyms

CAP1; PROSTASIN;

Species

Homo sapiens

Ensembl Protein

ENSP00000319730

InnateDB Gene

IDBG-27861 (PRSS8)

Protein Structure

UniProt Annotation

Function

Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G). {ECO:0000269PubMed:15246975, ECO:0000269PubMed:15474520}.

Subcellular Localization

Prostasin: Cell membrane; Single-pass membrane protein.Prostasin light chain: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus.Prostasin heavy chain: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus.

Disease Associations

Tissue Specificity

Found in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus and renal proximal tubular cells. In the prostate gland it may be synthesized in epithelial cells, secreted into the ducts, and excreted into the seminal fluid.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0010765	positive regulation of sodium ion transport

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel

PFAM

PF00089
PF09342

PRINTS

PR00722

PIRSF

SMART

SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt