InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRSS36

Summary

InnateDB Protein

IDBP-27881.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRSS36

Protein Name

protease, serine, 36

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000268281

InnateDB Gene

IDBG-27879 (PRSS36)

Protein Structure

UniProt Annotation

Function

Serine protease. Hydrolyzes the peptides N-t-Boc-Gln- Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a preference for substrates with an Arg instead of a Lys residue in position P1.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:15536082}. Note=Not attached to membranes.

Disease Associations

Tissue Specificity

Expressed in fetal kidney, skeletal muscle, liver, placenta and heart. Also expressed in tumor cell lines derived from lung and colon adenocarcinomas. {ECO:0000269PubMed:15536082}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel
IPR017326 Peptidase S1A, polyserase-2

PFAM

PF00089
PF09342

PRINTS

PR00722

PIRSF

PIRSF037933

SMART

SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References