InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OXA1L

Summary

InnateDB Protein

IDBP-2795.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OXA1L

Protein Name

oxidase (cytochrome c) assembly 1-like

Synonyms

OXA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000350740

InnateDB Gene

IDBG-2791 (OXA1L)

Protein Structure

UniProt Annotation

Function

Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria. {ECO:0000269PubMed:17936786, ECO:0000269PubMed:7991568}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000269PubMed:17936786}; Multi-pass membrane protein {ECO:0000269PubMed:17936786}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0097177	mitochondrial ribosome binding

Biological Process

GO:0006461	protein complex assembly
GO:0009060	aerobic respiration
GO:0032780	negative regulation of ATPase activity
GO:0032981	mitochondrial respiratory chain complex I assembly
GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly
GO:0051205	protein insertion into membrane
GO:0051262	protein tetramerization
GO:0051354	negative regulation of oxidoreductase activity
GO:0055114	oxidation-reduction process
GO:0097031	mitochondrial respiratory chain complex I biogenesis

Cellular Component

GO:0005739	mitochondrion
GO:0005746	mitochondrial respiratory chain
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane
GO:0032592	integral component of mitochondrial membrane
GO:0043234	protein complex