InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BTF3

Summary

InnateDB Protein

IDBP-27993.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BTF3

Protein Name

basic transcription factor 3

Synonyms

BETA-NAC; BTF3a; BTF3b; NACB;

Species

Homo sapiens

Ensembl Protein

ENSP00000369965

InnateDB Gene

IDBG-27987 (BTF3)

Protein Structure

UniProt Annotation

Function

When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. {ECO:0000269PubMed:10982809}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10982809}. Nucleus {ECO:0000269PubMed:10982809}. Note=The heterodimer with NACA is cytoplasmic.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0015031	protein transport