Homo sapiens Protein: DGKH | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-28037.5 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | DGKH | ||||||||||||||||||
Protein Name | diacylglycerol kinase, eta | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000337572 | ||||||||||||||||||
InnateDB Gene | IDBG-28033 (DGKH) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization. {ECO:0000269PubMed:12810723, ECO:0000269PubMed:19710016}. | ||||||||||||||||||
Subcellular Localization | Cytoplasm. Cell membrane. Note=Translocated from the cytoplasm to endosomes in response to stress stimuli. Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association. Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Isoform 2 is ubiquitously expressed. Isoform 1 is expressed only in testis, kidney and colon. {ECO:0000269PubMed:12810723}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000756
Diacylglycerol kinase, accessory domain IPR001206 Diacylglycerol kinase, catalytic domain IPR001660 Sterile alpha motif domain IPR001849 Pleckstrin homology domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain IPR011510 Sterile alpha motif, type 2 IPR013761 Sterile alpha motif/pointed domain IPR021129 Sterile alpha motif, type 1 |
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PFAM |
PF00609
PF00781 PF00169 PF00130 PF07647 PF00536 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00045
SM00046 SM00454 SM00233 SM00109 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q86XP1 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q86XP1 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 160851 | ||||||||||||||||||
UniGene | Hs.733239 | ||||||||||||||||||
RefSeq | NP_821077 | ||||||||||||||||||
HUGO | HGNC:2854 | ||||||||||||||||||
OMIM | 604071 | ||||||||||||||||||
CCDS | CCDS9381 | ||||||||||||||||||
HPRD | 07237 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AB078967 AB078968 AK098302 AK302727 AL136527 AL139328 AL157932 AL833883 BC043292 | ||||||||||||||||||
GenPept | AAH43292 BAC05280 BAC66960 BAC66961 BAG63946 CAD38739 CAH71062 CAH71399 CAI16894 CAM13770 CAM14245 CAM23676 | ||||||||||||||||||