InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DGKH

Summary

InnateDB Protein

IDBP-28041.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DGKH

Protein Name

diacylglycerol kinase, eta

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000261491

InnateDB Gene

IDBG-28033 (DGKH)

Protein Structure

UniProt Annotation

Function

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization. {ECO:0000269PubMed:12810723, ECO:0000269PubMed:19710016}.

Subcellular Localization

Cytoplasm. Cell membrane. Note=Translocated from the cytoplasm to endosomes in response to stress stimuli. Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association. Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS.

Disease Associations

Tissue Specificity

Isoform 2 is ubiquitously expressed. Isoform 1 is expressed only in testis, kidney and colon. {ECO:0000269PubMed:12810723}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005524	ATP binding
GO:0046872	metal ion binding

Biological Process

GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007596	blood coagulation
GO:0016310	phosphorylation
GO:0030168	platelet activation
GO:0035556	intracellular signal transduction
GO:0051259	protein oligomerization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

PFAM

PF00609
PF00781
PF00169
PF00130

PRINTS

PIRSF

SMART

SM00045
SM00046
SM00233
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q86XP1