InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DECR1

Summary

InnateDB Protein

IDBP-28072.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DECR1

Protein Name

2,4-dienoyl CoA reductase 1, mitochondrial

Synonyms

DECR; NADPH; SDR18C1;

Species

Homo sapiens

Ensembl Protein

ENSP00000220764

InnateDB Gene

IDBG-28070 (DECR1)

Protein Structure

UniProt Annotation

Function

Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA.

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Heart = liver = pancreas > kidney >> skeletal muscle = lung. {ECO:0000269PubMed:7818482}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008670	2,4-dienoyl-CoA reductase (NADPH) activity
GO:0016491	oxidoreductase activity
GO:0016651	oxidoreductase activity, acting on NAD(P)H
GO:0070402	NADPH binding

Biological Process

GO:0006635	fatty acid beta-oxidation
GO:0008152	metabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0051289	protein homotetramerization
GO:0055114	oxidation-reduction process