InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PYDC1

Summary

InnateDB Protein

IDBP-28120.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PYDC1

Protein Name

PYD (pyrin domain) containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000304336

InnateDB Gene

IDBG-28118 (PYDC1)

Protein Structure

UniProt Annotation

Function

Associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro- caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS. {ECO:0000269PubMed:12656673}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12656673}.

Disease Associations

Tissue Specificity

Predominantly expressed in monocytes, macrophages and granulocytes. {ECO:0000269PubMed:12656673}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006469	negative regulation of protein kinase activity
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0045087	innate immune response
GO:0050718	positive regulation of interleukin-1 beta secretion