InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RGNEF

Summary

InnateDB Protein

IDBP-28233.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGNEF

Protein Name

Rho-guanine nucleotide exchange factor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000296794

InnateDB Gene

IDBG-231005 (RGNEF)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0046872	metal ion binding

Biological Process

GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00621
PF00169
PF00130
PF11929
PF12796

PRINTS

PIRSF

SMART

SM00325
SM00233
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8N1W1