InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARID2

Summary

InnateDB Protein

IDBP-28400.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARID2

Protein Name

AT rich interactive domain 2 (ARID, RFX-like)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000335044

InnateDB Gene

IDBG-28398 (ARID2)

Protein Structure

UniProt Annotation

Function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. {ECO:0000269PubMed:16782067}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Highly expressed in heart and testis. {ECO:0000269PubMed:16782067}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005488	binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006337	nucleosome disassembly
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016568	chromatin modification