InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CNGA4

Summary

InnateDB Protein

IDBP-28543.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNGA4

Protein Name

cyclic nucleotide gated channel alpha 4

Synonyms

CNCA2; CNG-4; CNG4; CNG5; CNGB2; OCNC2; OCNCb; OCNCBETA;

Species

Homo sapiens

Ensembl Protein

ENSP00000369268

InnateDB Gene

IDBG-28539 (CNGA4)

Protein Structure

UniProt Annotation

Function

Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005222	intracellular cAMP activated cation channel activity
GO:0005223	intracellular cGMP activated cation channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0030552	cAMP binding
GO:0030553	cGMP binding

Biological Process

GO:0006811	ion transport
GO:0007603	phototransduction, visible light
GO:0007608	sensory perception of smell
GO:0042391	regulation of membrane potential
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport